Covid US: New ‘Delta Plus’ variant that may have originated in Nepal is found in 85 patients

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A new coronavirus variant carrying a mutation that appears to make it more transmissible has been detected in the U.S.

The variant, called AY.1 or ‘Delta plus,’ is a sub-lineage of the mutant strain that was first detected in India and is spreading across the globe.

It has acquired the spike protein mutation called K417N, which is also found in the Beta variant first identified in South Africa

Some scientists worry that the mutation, coupled with other existing features of the Indian ‘Delta’ variant, may lead to it spreading more easily.

It is currently unclear where the variant originated with some researchers saying it may have come from Nepal, others saying it first cropped up in India and a few suggesting Europe is the origin point.

According to a recent report from the UK government, at least 85 cases have been found in America, but there is no evidence that Delta plus is rapidly spreading across the country.

As of June 16, at least 85 cases of the 'Delta plus' coronavirus variant - which has a mutation that makes it more transmissible - have been detected in the U.S.

As of June 16, at least 85 cases of the ‘Delta plus’ coronavirus variant – which has a mutation that makes it more transmissible – have been detected in the U.S.

Samples have been found in California, Connecticut, Maryland, New York, Tennessee, Vermont and Washington as early as April 22, but there is no evidence the variant is rapidly spreading

Samples have been found in California, Connecticut, Maryland, New York, Tennessee, Vermont and Washington as early as April 22, but there is no evidence the variant is rapidly spreading

‘We need to determine how susceptible it is to neutralization,’ Dr David Montefiori, a professor in surgery at Duke University, told DailyMail.com.

‘The key feature of every new variant that everyone wants to know right away is neutralization. Neutralizing antibodies are the primary way that the vaccines work.

‘I would predict this new mutation is not going to change things much bu we don’t know until it’s tested.’

As of June 16, at least 197 cases has been found in 11 countries: Britain, Canada, India, Japan, Nepal, Poland, Portugal, Russia, Switzerland, Turkey and the U.S. 

The earliest case in India is from a sample taken on April 5 and health ministers say around 40 cases have been observed in the states of Maharashtra, Kerala and Madhya Pradesh, with ‘no significant increase in prevalence’. 

Britain said its first five cases were sequenced on April 26 and they were contacts of individuals who had travelled from, or transited through, Nepal and Turkey.

No deaths were reported among the UK and Indian cases.

Meanwhile, according to outbreak.info, the variant was first detected in the U.S. on April 22 and it makes up less than 0.5 percent of cases.

The website lists California, Connecticut, Maryland, New York, Tennessee, Vermont and Washington as the states where samples have been identified. 

Dr Peter Chin-Hong, a professor of medicine and infectious disease specialist at the University of California, San Francisco, says there is no evidence Delta plus is spreading yet, but that the U.S. needs to stay vigilant. 

‘The backend of this variant is Delta, which is the scariest one so far,’ he told DailyMail.com.

‘The “plus” gives it even more superpowers than Delta, which is potentially even a scarier situation. It gives the virus an advantage to live.

‘So I think it follows the same playbook [as Delta] We’ll have to see what the rate of increase is, which we don’t know yet.’  

Studies are ongoing in India and globally to test the effectiveness of vaccines against this mutation.

‘WHO is tracking this variant as part of the Delta variant, as we are doing for other Variants of Concern with additional mutations,’ the World Health Organization (WHO) said in a statement sent to Reuters.

‘For the moment, this variant does not seem to be common, currently accounting for only a small fraction of the Delta sequences…Delta and other circulating Variants of Concern remain a higher public health risk as they have demonstrated increases in transmission.’

A virologist in India said the Delta plus variant may reduce the effectiveness of COVID-19 antibody treatments due to the K417N mutation. Pictured: A student is vaccinated in Mumbai, June 22

A virologist in India said the Delta plus variant may reduce the effectiveness of COVID-19 antibody treatments due to the K417N mutation. Pictured: A student is vaccinated in Mumbai, June 22

But India’s health ministry warned that regions where it has been found ‘may need to enhance their public health response by focusing on surveillance, enhanced testing, quick contact-tracing and priority vaccination.’

Shahid Jameel, a top Indian virologist, told Reuters the K417N was known to reduce the effectiveness of a cocktail of therapeutic monoclonal antibodies. 

There are worries Delta plus would inflict another wave of infections on India after it emerged from the world’s worst surge in cases only recently. 

‘The mutation itself may not lead to a third wave in India – that also depends on COVID-appropriate behavior, but it could be one of the reasons,’ said Tarun Bhatnagar, a scientist with the state-run Indian Council for Medical Research, in a statement.

Chin-Hong said it’s important not to panic, but that the public should remain vigilant.

‘This is a wake up call that virus is continuing to be a shapeshifter,’ he said.

‘Don’t put off your vaccine or encourage the people in your community to get it. If we are afraid of Delta, Delta plus is potentially scarier. If there was ever a time to get it, now is the time.’

Montefioiri added: ‘ My biggest fear is variant like Delta variant which spreads very fast and will acquire mutations in the spike protein which would make it evade our vaccines.’

What do we know about the ‘Delta plus’ variant’? 

Real name: Delta+K417N, Delta plus, or AY.1

When and where was it discovered?

Some scientists believe the variant first emerged in Nepal after the Indian variant mutated.

Scientists believe the country is the most likely origin of the virus because of its similarities to the Indian variant, and the detection of so many cases on flights from the Himalayan nation.

Only three cases has been identified in Nepal, but the country carries out very little Covid surveillance. 

Other scientists say the variant was first detected in India and some say Europe is the origin point. 

What mutations does it have?

The variant is a mutated version of the Indian type but with a new mutation — called K417N — which has also been spotted on the South African variant. 

Is it more infectious and can it evade vaccines?

There are no studies at present showing whether it is more infectious or can evade vaccines compared to other variants.

But scientists fear it has combined the worst features of the the Indian and South African variants, making it more transmissible and more resistant to vaccines.    

How deadly is it?

It is not clear whether the mutant strain is more deadly, but it is being watched closely by scientists.

Studies suggest the Indian variant is not more deadly than the original virus — but it may raise the risk of infected patients being hospitalized.

How many cases have been detected in the UK?

The variant has been spotted at least 38 times in the UK, according to a report from the government and 85 times in the US. 

However, that reflects the number of times the strain has been sequenced, meaning the same person testing twice would come up as two counts.

The variant had arrived on American soil by April 22 and on British soil by April 26, sequencing data suggests.  

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